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以1龄草鱼为试验对象,对防治草鱼出血病有效的碘和PVP—碘,用Na~(125)I作示踪剂,研究了口灌给药后的体内浓度和PVP—碘浸浴后的体内浓度。口灌碘24μg/g后,可在1h时血药浓度达到(1.22±0.016)μg/ml的峰值。其有效浓度维持3h。实际口服量为23.41mg/kg。日给药多次为宜。口灌PVP—碘96μg/g后,血药峰值为(1.81±0.01)μg/ml,低于其MEC(11.9μg/ml)。用PVP—碘浸洗后,从0～4h的浓度以内脏>皮肤>鳃>肌肉。除肌肉以0h的药浓度最低,2h达到峰值之外,其他组织器官的在0h达峰值。PVP—碘作浸洗消毒剂比口服有效。
The first-instar grass carp was used as experimental object to study the effect of oral administration of iodine and PVP-iodine on the prevention and treatment of grass carp hemorrhage using Na ~ (125) I as a tracer. In vivo concentration. After oral administration of iodine 24μg / g, the plasma concentration reached the peak of (1.22 ± 0.016) μg / ml at 1h. The effective concentration of 3h. The actual oral dose of 23.41mg / kg. Daily administration is appropriate. After PVP-iodine 96 μg / g, the plasma peak value was (1.81 ± 0.01) μg / ml, lower than that of MEC (11.9 μg / ml). After dipping with PVP-iodine, viscera> skin> gills> muscle from 0 to 4 hours. In addition to the lowest concentration of muscle medicine 0h, 2h peak, the other tissues and organs in the peak at 0h. PVP-iodine for dipping disinfectant than oral effective.