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采用体外组织培养法观察α－促黑素细胞激素（α－ＭＳＨ）对白细胞介素－１β（ＩＬ－１β）刺激家兔下丘脑组织释放前列腺素Ｅ２（ＰＧＥ２）的影响。结果显示，ＩＬ－１β与下丘脑组织培养后４０ｍｉｎ，培养上清液中ＰＧＥ２含量高于未加ＩＬ－１β的对照组（Ｐ＜００１）；而预先（２０ｍｉｎ）加入α－ＭＳＨ，再加入同量ＩＬ－１β培养４０ｍｉｎ，则培养上清液的ＰＧＥ２含量接近对照组水平（Ｐ＞００５）。α－ＭＳＨ抑制下丘脑ＰＧＥ２的产生，可能是其解热的重要机制之一。
The effect of α-melanocyte-stimulating hormone (α-MSH) on the release of prostaglandin E2 (PGE2) in hypothalamus of rabbits stimulated by interleukin-1β (IL-1β) was observed by in vitro tissue culture. The results showed that the content of PGE2 in supernatant of IL-1β and hypothalamus after culture for 40min was higher than that of the control group without IL-1β (P <001), while α-MSH was added in advance (20min) Adding the same amount of IL-1β for 40min, the culture supernatant PGE2 content close to the control group (P> 005). α-MSH inhibits hypothalamic PGE2 production may be one of its important mechanisms of antipyretic.