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不同个体在乙型肝炎病毒(HBV)感染后的免疫学和临床转归不同,这与宿主的人类白细胞抗原(human leukocyte antigens,HLA)等免疫遗传学背景和HBV自身特性均相关。HLA-I类基因的型别和HBV抗原的序列特点,共同决定某一宿主的抗原呈递细胞(antigen-presenting cell,APC)能
Different individuals have different immunological and clinical outcomes after Hepatitis B virus (HBV) infection, which is related to host immune genetic background such as human leukocyte antigens (HLA) and HBV self-identity. The type of HLA-I gene and the sequence characteristics of HBV antigens jointly determine the antigen-presenting cell (APC) energy of a host