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冷凝集素病是多种原因引起的一种自身免疫性、溶血性贫血。一般可分为原发性和继发性两大类型。原发性、慢性冷凝集素病综合征,病因不明,主要临床表现是:遇冷时出现血管内凝血、手足发绀、溶血性贫血及发作性血红蛋白尿。四十至八十岁的病人常表现为淋巴增殖性疾患,五十至六十岁为发病之高峰年龄,亦可以发展成典型的淋巴瘤。继发性(或一过性)冷凝集素病多因血中冷凝集素滴度增高所致,可并发于多种疾病,但罕见于溶血性疾患者。所谓冷凝集素乃是一种能固定补体的、
Cold agglutinin disease is caused by a variety of causes of an autoimmune, hemolytic anemia. Generally can be divided into two types of primary and secondary. Primary, chronic cold agglutinin syndrome, the etiology is unknown, the main clinical manifestations are: in the event of intravascular coagulation, cyanosis, hemolytic anemia and episodic hemoglobinuria. Patients between the ages of 40 and 80 often show lymphoproliferative disorders. The patients aged between 50 and 60 are at the peak age of onset and can also develop into typical lymphomas. Secondary (or transient) cold agglutinin disease mostly due to blood cold agglutinin titers increased, may be complicated by a variety of diseases, but rare in patients with hemolytic disease. The so-called cold agglutinin is a fixed complement,