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壳聚糖(chitosan)生产已有多年历史,生产中一个关键问题是脱乙酰反应,因为该反应完成的程度决定了反应产物即壳聚糖的生物活性。我国20世纪60年代以来的工艺过程基本没有大的变革,浓碱(45％~50％氢氧化钠)和高温(100℃~120℃)一直是脱乙酰反应的主要参数。得出的产物尚不令人满意。
Chitosan has been produced for many years and one of the key problems in the production is the deacetylation reaction, because the degree of completion of the reaction determines the biological activity of the reaction product, chitosan. China’s process of the 1960s has basically no major changes, concentrated alkali (45% ~ 50% sodium hydroxide) and high temperature (100 ℃ ~ 120 ℃) has been the main parameter of the deacetylation reaction. The resulting product is not yet satisfactory.