论文部分内容阅读
摘要目的塑造一种适用于PET放射性示踪剂的2型趋化因子受体(CCR2)-结合肽,用以无创性检测肺创伤鼠模型和从肺病病人中获取的肺组织中的肺炎症。材料与方法本研究获得了动物和人类研究机构委员会的批准。病人均签署知情同意书。一种7-氨基酸CCR2结合肽[外环1变型(ECL1i)]与DOTA共轭结合,并用64Cu或荧光染色。19只野
Abstract Objective To create a type 2 chemokine receptor (CCR2) -binding peptide for PET radiotracers for the noninvasive detection of pneumonitis in lung tissue from lung trauma rats and lung tissue obtained from patients with lung disease. Materials and Methods The study was approved by the Animal and Human Research Institutions Commission. All patients signed informed consent form. A 7-amino acid CCR2 binding peptide [outer loop 1 variant (ECL1i)] is conjugated to DOTA and stained with 64Cu or fluorescent. 19 wild