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目的探讨局部光动力治疗(photodynamic therapy,PDT)并影像引导下适形调强治疗(Image guide radiation therapy,IGRT)同步中药辅助整合对肿瘤治疗的剂量效应及临床疗效,为中晚期空腔脏器及表浅肿瘤患者提供不同策略有效综合治疗的依据。方法对160例手术失败或无手术适应症的空腔或浅表肿瘤患者,采用局部与区域联合全身的综合治疗方案,观察分析20min vs.30min、200J/cm2vs.300J/cm2、1次vs.3次光化物理疗法(PCT/PDT)不同时间、剂量、分次(TDF)与IGRT并同步中医药治疗的量效关系。结果 PDT物理疗法与IGRT同步中医药治疗,随着TDF的变化有显著统计意义,PDT对中晚期肿瘤特别是空腔脏器患者,可显著减轻症状,提高患者生活质量;对梗阻型、放化疗失败的中晚期肿瘤患者有较高姑息治疗价值。结论采用PDT联合IGRT与中药不同策略的整合治疗,通过TDF的优化同步中医药的辅助方案,创伤性小、副作用少,可达到减毒增效、带瘤生存的目的,使中晚期空腔脏器及表浅肿瘤患者“变不治为可治”。
Objective To investigate the dose-response and clinical effect of photodynamic therapy (PDT) combined with Image guide radiation therapy (IGRT) on traditional Chinese medicine (TCM) And superficial tumor patients with different strategies to provide an effective basis for comprehensive treatment. Methods A total of 160 cases of cavity or superficial tumor with unsuccessful or unsuccessful operation were treated with local and regional combined systemic therapy. The observation and analysis of 20min vs. 30min, 200J / cm2 vs 300J / cm2, 3 times photochemical therapy (PCT / PDT) at different times, doses, times (TDF) and IGRT and simultaneous dose-effect relationship of traditional Chinese medicine. Results PDT physical therapy and IGRT synchronous Chinese medicine treatment, with the change of TDF was statistically significant, PDT in advanced tumors, especially patients with hollow organs, can significantly reduce the symptoms and improve patient quality of life; obstruction, radiotherapy and chemotherapy Patients with failed advanced cancer have a higher palliative value. Conclusions The combination of PDT with IGRT and different strategies of traditional Chinese medicine can achieve the purpose of reducing the toxicity and increasing the tumor survival through TDF’s optimized synchronous Chinese medicine auxiliary program with less trauma and fewer side effects, Patients and superficial tumors “changeable to be curable ”.