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目的对安徽省蚌埠市第三人民医院抗肿瘤药物奥沙利铂临床应用情况进行回顾性调查并评价。方法调查该院2012年1月~2013年6月使用奥沙利铂的病例,评价其用药合理性及安全性。结果 2012年1月~2013年6月该院使用奥沙利铂的患者90例,符合说明书适应证有45例(占50.00%),符合《指南》推荐病种用药的患者67例(占74.44%),不良反应主要为造血系统、消化系统及神经系统损害。结论奥沙利铂在临床应用中存在超说明书适应证用药,用法用量不规范,临床医师对神经系统毒性反应监测意识不强,临床药师应以此为工作切入点,促进临床合理用药。
Objective To retrospectively evaluate the clinical application of oxaliplatin in the Third People’s Hospital of Bengbu City, Anhui Province. Methods The hospital from January 2012 to June 2013 using oxaliplatin in the case, evaluate the rationality and safety of medication. Results From January 2012 to June 2013, 90 patients were treated with oxaliplatin in this hospital. There were 45 patients (50.00%) in compliance with the instructions and 67 patients (74.44%) who met the recommended disease type %), Adverse reactions mainly hematopoietic system, digestive system and nervous system damage. Conclusion Oxaliplatin in the clinical application of indications over the use of indications, dosage usage is not standardized, clinicians on the nervous system toxicity monitoring awareness is not strong, clinical pharmacists should use this as a starting point for the promotion of clinical rational use of drugs.