骨髓增生异常综合征(MDS)是一种表现为造血紊乱和无效造血的骨髓干细胞疾病。外周血中一系或多系细胞减少,大多数病人死于出血及感染。作者收治三例老年MDS病人,年龄66～73岁。表现为贫血、血小板减少,皮肤粘膜出血,外周血中红细胞大小不一,巨大红细胞,偶见有核红细胞和幼粒细胞。骨髓涂片和活检增生旺盛或低下,红系或粒系或巨核系生成不良。二例Coombs’试验阳性。根据FAB标准诊断为MDS,给予强的松、氟 Myelodysplastic syndrome (MDS) is a bone marrow stem cell disorder characterized by hematopoietic disorders and ineffective hematopoiesis. One or more peripheral blood cells decreased, the majority of patients died of bleeding and infection. The author admitted to three elderly MDS patients, aged 66 to 73 years. The performance of anemia, thrombocytopenia, skin and mucous membrane bleeding, peripheral blood red blood cell size varies, huge red blood cells, occasional nucleated erythrocytes and promyelocytic. Bone marrow smear and biopsy hyperplasia or low, erythroid or myeloid or megakaryocyte dysplasia. Two cases of Coombs’ test positive. According to FAB standard diagnosis of MDS, given prednisone, fluorine