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目的探讨妊娠期高血压疾病(HDCP)患者肝肾功能指标监测的临床意义。方法分析109例HDCP患者(包括妊娠高血压组、轻度子痫前期组和重度子痫前期组)和66例健康妊娠组的初诊建卡时及孕末期血清尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、谷丙转氨酶(ALT)和谷草转氨酶(AST)等指标,了解其变化情况及与HDCP的关联性。结果各组间孕末期UA值均显著高于初诊建卡时。与健康妊娠组相比,重度子痫前期组孕末期UA值和Cr值改变显著(P<0.01)。各组间孕末期BUN、ALT和AST指标变化也无显著差异(P>0.05)。结论在HDCP孕妇的肝肾功能各项指标中,血清UA对于预测HDCP的发展意义最显著。
Objective To investigate the clinical significance of monitoring liver and kidney function in patients with gestational hypertension (HDCP). Methods The levels of serum urea nitrogen (BUN) and creatinine (Cr) in 109 patients with HDCP (including gestational hypertension, mild preeclampsia and severe preeclampsia) and 66 healthy pregnant women ), Uric acid (UA), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured to understand their changes and their association with HDCP. Results The UA value of each group during the end of pregnancy was significantly higher than that of newly diagnosed card. Compared with healthy pregnancy group, the values of UA and Cr in pregnant women with severe preeclampsia changed significantly at the end of pregnancy (P <0.01). There was no significant difference in BUN, ALT and AST index between the three groups at the end of pregnancy (P> 0.05). Conclusion Among the indicators of liver and kidney function in HDCP pregnant women, serum UA has the most significant significance in predicting the development of HDCP.