论文部分内容阅读
目的探讨血清睫状神经营养因子(CNTF)水平与T2DM及肥胖的相关性与临床意义。方法选择44名糖耐量正常(NGT组)者和44例新诊断T2DM(T2DM组)患者按BMI各自分为超重(Ob)和正常体重(Nob)亚组。ELISA法测定血清CNTF水平。结果 T2DM组血清CNTF的浓度较NGT组降低(P<0.05)。相关分析显示,T2DM组中CNTF与TC、HbA1c、FPG、HOMA-IR呈负相关。HOMA-IR是血清CNTF的独立相关因素。结论 T2DM患者CNTF水平降低,与TC、HbA1c、FPG、HOMA-IR呈负相关,HOMA-IR是CNTF独立相关因素。
Objective To investigate the correlation between serum ciliary neurotrophic factor (CNTF) and T2DM and obesity and its clinical significance. Methods Forty-four patients with normal glucose tolerance (NGT) and 44 patients with newly diagnosed T2DM (T2DM) were divided into two groups according to BMI: Ob and Nob. The level of serum CNTF was measured by ELISA. Results The concentration of serum CNTF in T2DM group was lower than that in NGT group (P <0.05). Correlation analysis showed that CNTF was negatively correlated with TC, HbA1c, FPG and HOMA-IR in T2DM group. HOMA-IR is an independent and related factor of serum CNTF. Conclusions The level of CNTF in T2DM patients is decreased, but negatively correlated with TC, HbA1c, FPG and HOMA-IR. HOMA-IR is an independent factor related to CNTF.