论文部分内容阅读
具有相似临床适应证的氟喹诺酮类抗菌药均存在诱发心血管不良反应及血糖代谢障碍的潜在风险。若干易感因素(如糖尿病、心脏病及同时接受某些药物治疗等)可能增加相关严重不良反应事件发生的危险程度。在对1990-2010年间相关英文文献进行科学筛选及分类(病例/系列报道、观察性研究、随机临床试验及药物警戒研究)的基础上,本文较系统地综述了与氟喹诺酮治疗相关的心血管及代谢安全性,旨在为临床医师选择适宜的氟喹诺酮和制定合理的个体化用药方案以及今后的相关研究提供帮助和指导。
Fluoroquinolone antibacterials with similar clinical indications have the potential risk of inducing cardiovascular adverse reactions and disorders of blood glucose metabolism. A number of susceptibility factors (such as diabetes, heart disease and concurrent medication) may increase the risk of serious adverse events. Based on the scientific screening and classification of relevant English articles (case / series reports, observational studies, randomized clinical trials and pharmacovigilance studies) from 1990 to 2010, this review provides a systematic review of the cardiovascular related to fluoroquinolone therapy And metabolic safety, aimed at providing assistance and guidance for clinicians to choose the appropriate fluoroquinolones and to formulate rational individualized drug regimens and related research in the future.