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目的对胃得安片改善应激性胃溃疡的作用及机制进行研究。方法采用束缚水浸应激法建立胃溃疡大鼠模型,分析胃组织病理切片,检测胃黏膜损伤指数、血清一氧化氮(NO)和胃组织前列腺素(PGE_2)含量。结果与模型组比较,各给药组血清NO、胃组织PGE_2含量显著升高(P<0.05,P<0.01),大鼠胃黏膜损伤指数显著降低(P<0.05,P<0.01);与正常对照组相比,胃得安高剂量给药组NO含量和胃黏膜形态接近于正常组水平。结论胃得安片能够通过增加血清NO和胃组织PGE_2的含量,抑制胃黏膜细胞损伤,从而改善应激性刺激导致的大鼠胃溃疡病变。
Objective To study the effect and mechanism of Weidean An on stress ulcer. Methods The rat model of gastric ulcer was established by irrigated water immersion method. The gastric mucosal injury index, serum nitric oxide (NO) and the content of prostaglandin (PGE 2) in gastric tissue were detected. Results Compared with the model group, the content of NO and the content of PGE_2 in gastric tissue in each administration group were significantly increased (P <0.05, P <0.01), and the gastric mucosal lesion index was significantly decreased (P <0.05, P <0.01) Compared with the control group, the NO content and the gastric mucosa morphology of the high dosage group of Weidean were close to those of the normal group. Conclusion Weidean An Tablet can improve the gastric ulcer lesion caused by stress stimulation by increasing the content of NO and the content of PGE_2 in gastric tissue and inhibiting the gastric mucosal cell injury.