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本文对我科自1982年8月至1991年12月间检出的22例平衡易位携带者进行分析,结果显示:此组病人以反复自然流产而就诊者最多,占77.27％;其次是曾分娩畸形儿死胎者,占9.09％。染色体核型分析以罗伯逊易位为最多,占81.82％,其中非同源染色体罗伯逊易位占77.78％,同源染色体罗伯逊易位占22.22％;染色体相互易位占18.18％。本文建议同源染色体罗伯逊易位者,应劝其绝育,非同源染色体平衡易位者,可于孕中期取羊水细胞培养进行产前诊断。
In this paper, our department from August 1982 to December 1991 detected 22 cases of balanced translocation carriers were analyzed, the results showed that: This group of patients with recurrent spontaneous abortion and the largest number of patients, accounting for 77.27%; followed by a Deformity of childbirth stillbirth, 9.09%. Chromosomal karyotype analysis with Robertson translocation as the most, accounting for 81.82%, of which non-homologous chromosome Robertson translocation accounted for 77.78%, homologous Robertson translocation accounted for 22.22%; chromosomal translocation accounted for 18.18%. This paper suggests that homologous chromosome Robertson translocation, should be advised to its sterilization, non-homologous chromosome translocation who can be taken in the second trimester amniotic fluid cell culture for prenatal diagnosis.