论文部分内容阅读
目的：观察α干扰素（ＩＦＮ－α）治疗慢性乙型肝炎时干扰素抗体（抗－ＩＦＮ）的变化，并探讨其临床意义。方法：用复合免疫微球法（ＣＩＶＲ）检测干扰素抗体。结果：ＩＦＮ－α治疗后患者血清抗－ＩＦＮ有所增加，抗－ＩＦＮ的存在与否对疗效有显著影响（Ｐ＜０．０５）。抗－ＩＦＮ在治疗前已阳性和治疗后才转阳性的患者，对ＩＦＮ－α治疗的反应可能有一定差异。结论：抗－ＩＦＮ出现对ＩＦＮ－α的疗效有一定影响。
Objective: To observe the change of interferon antibody (anti-IFN) in patients with chronic hepatitis B treated with IFN-α and explore its clinical significance. Methods: The interferon antibodies were detected by CIMR. Results: Serum anti-IFN was increased after treatment with IFN-α, and the presence or absence of anti-IFN had a significant effect on the efficacy (P <0.05). Anti-IFN in patients who were positive before treatment and positive after treatment may respond differently to IFN-α therapy. Conclusion: The anti-IFN appears to have a certain effect on the efficacy of IFN-α.