神经分化因子(NeuroD)是一种含bHLH结构域的结合E-box的转录调控因子,主要参与神经细胞分化过程和胰腺发生、功能维持。近年来的研究表明,NeuroD的表达受细胞因子调控或某些化学因子影响,同时与多种蛋白,如Brg1,AK1和Htt等共同调节下游基因表达,进而调控细胞周期和神经细胞分化进程。这些研究为NeuroD参与细胞分化进程,糖尿病和其他神经性疾病的发生提供了依据。 Neuronal differentiation factor (NeuroD) is a transcription factor that binds to the E-box containing the bHLH domain and is mainly involved in neural cell differentiation and pancreatic development and maintenance. In recent years, studies have shown that NeuroD expression is regulated by cytokines or certain chemical factors, and simultaneously with a variety of proteins such as Brg1, AK1 and Htt regulate the downstream gene expression, and thus regulate the cell cycle and neural cell differentiation process. These studies provide the basis for the involvement of NeuroD in the process of cell differentiation, diabetes and other neurological diseases.