【摘 要】
：
A two-layer method based on support vector machines (SVMs) has been developed to distinguish epoxide hydrolases (EHs) from other enzymes and to classify its sub
【机 构】
：
James. D. Watson Institute of Genome Sciences,Department of Chemistry
论文部分内容阅读
A two-layer method based on support vector machines (SVMs) has been developed to distinguish epoxide hydrolases (EHs) from other enzymes and to classify its subfamilies using its primary protein sequences. SVM classifiers were built using three different feature vectors extracted from the primary sequence of EHs: the amino acid composition (AAC), the dipeptide composition (DPC), and the pseudo-amino acid composition (PAAC). Validated by 5-fold cross tests, the first layer SVM classifier can differentiate EHs and non-EHs with an accuracy of 94.2% and has a Matthew,s correlation coefficient (MCC) of 0.84.Using 2-fold cross validation, PAAC-based second layer SVM can further classify EH subfamilies with an overall accuracy of 90.7% and MCC of 0.87 as compared to AAC (80.0%) and DPC (84.9%). A program called EHPred has also been developed to assist readers to recognize EHs and to classify their subfamilies using primary protein sequences with greater accuracy.
其他文献
By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switc
李某,男,16岁,学生.2002年5月9日初诊.主诉:头昏、不能行走2月余,阵发性抽搐、角弓反张1月余.
The precise detection of flaw echoes buried in backscattering noise caused by material microstructure is a problem of great importance in ultrasonic non-destruc
In e-commerce the multidimensional data analysis for OLAP (on-line analytical processing) based on the web data needs integrating various data sources such as X
近些年,一些职高学校的语文教师反映在职高学校中开展语文课程难度较以往有所增加。这种现象主要是由几方面原因造成的,其中,由于社会变更速度加快,人们的心理随之不断变化,
在推进素质教育，推进自主学习的宏观进程中，围绕如何选择有效的教学途径，提高学生学习效率的问题，可谓仁者见仁，智者见智，争议颇多。做为一个中学教师，近年来，我在认真学习教育理论的
Treated FeS2 samples were prepared by natural FeS2 samples which were ground first,heated in nitrogen and then washed in acid. The levels of impurity elements,
This paper reviews the investigation status of the techniques for preparation of metal matrix composites and the research outcomes achieved recently. The mechan
1,3-propanediol (1,3-PD) is an important material for chemical industry, and there has been always much interest in the production of 1,3-PD using all possible
中国数据中心产业发展联盟主办、中国IDC产业联盟网承办的“2011中国数据中心产业发展大会（第一届）”于3月22日在北京召开。峰会围绕国内数据中一心领域产业发展、规划建设、市