L-核酮糖是高价值稀有糖,它是合成抗病毒药物的重要前体。系统地综述了L-核酮糖的化学合成和分别以L-阿拉伯糖、核糖醇、L-核糖等为原料的生物合成制备L-核酮糖的研究进展,深入分析了其中存在的问题,并比较了不同生物合成途径的转化率和生产速率的差异。最后,展望了未来研究的主要发展趋势。 L-ribulose is a high-value, rare sugar that is an important precursor for the synthesis of antiviral drugs. The progress in the synthesis of L-ribulose by biosynthesis of L-arabinose, ribitol and L-ribose, respectively, was systematically reviewed. The existing problems were analyzed in detail. The differences in conversion rates and production rates of different biosynthetic pathways were also compared. Finally, the main trends of future research are prospected.