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西地那非可以有效的治疗勃起功能障碍(ED),也常常被应用于尿毒症肾移植术后的患者中。由于通过细胞色素P450 3A4这一共同代谢清除路径,西地那非与他克莫司之间具有药代动力学方面的相互作用。因此,ChristB等进行研究以探讨联合应用这两种药物9d的药代动力学。共入选了9位男性患者(29～52岁),这些患者在近期刚刚接受了单次应用西地那非与他克莫司相互作用的研究。联合给药方法保持不变,从而避免引入混淆因素。这些
Sildenafil is effective in the treatment of erectile dysfunction (ED) and is also commonly used in patients after urethral kidney transplantation. Sildenafil and tacrolimus have pharmacokinetic interactions due to the common metabolic clearance pathway of cytochrome P450 3A4. Therefore, ChristB and other studies to explore the combination of these two drugs 9d pharmacokinetics. Nine men (29-52 years) were enrolled and these patients have recently received a single study of the interaction of sildenafil with tacrolimus. The method of co-administration remains unchanged, thereby avoiding the introduction of confounding factors. These ones