论文部分内容阅读
目的观察前列地尔联合氯沙坦治疗老年糖尿病肾病患者的临床效果。方法将糖尿病肾病患者127例随机分为观察组63例和对照组64例,均严格控制血脂及血糖,对照组给予前列地尔治疗;观察组在此基础上给予氯沙坦钾片治疗,治疗结束后统计2组疗效并检测患者尿素氮(BUN)、肌酐(Cr)和24h尿蛋白(24h UP)水平。结果观察组总有效率为88.9%明显高于对照组的73.4%,差异有统计学意义(P<0.05);治疗后2组患者BUN、Cr和24h UP均低于治疗前,其中观察组Cr和24h UP的水平明显低于对照组,差异均有统计学意义(P<0.05)。结论前列地尔联合氯沙坦治疗老年糖尿病肾病患者的临床疗效确切,能降低尿蛋白的产生,对肾功能有明显改善,值得临床推广。
Objective To observe the clinical effect of alprostadil plus losartan in the treatment of elderly patients with diabetic nephropathy. Methods A total of 127 patients with diabetic nephropathy were randomly divided into observation group (63 cases) and control group (64 cases). Blood lipids and blood glucose were controlled strictly. The control group was treated with alprostadil. The observation group was treated with losartan potassium tablets. At the end of the study, two groups of curative effect were measured and the levels of BUN, Cr and 24h UP in patients were measured. Results The total effective rate in the observation group was 88.9%, which was significantly higher than that in the control group (73.4%), the difference was statistically significant (P <0.05). After treatment, the BUN, Cr and 24h UP in two groups were lower than before treatment, And 24h UP levels were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Alprostadil combined with losartan in elderly patients with diabetic nephropathy clinical curative effect is exact, can reduce the production of urinary protein, renal function improved significantly, it is worth clinical promotion.