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目的:比较尼群地平和依那普利对具高原居留史高血压患者的疗效。方法:80名具高原居留高血压患者随机分为尼群地平和依那普利治疗组,分别给予尼群地平和依那普利10mg/d,观察血压变化,分别采用Elisa法和硝酸还原法检测血清中ET-1和NO含量。结果:对于具有高原居留史的高血压患者,依那普利和尼群地平均能降低其血压和升高舒血管物质NO的含量,降低缩血管物质ET-1的含量;且尼群地平的疗效要优于依那普利。结论:对于具高原居留史高血压患者,尼群地平疗效优于依那普利。
OBJECTIVE: To compare the efficacy of nitrendipine and enalapril in hypertensive patients with high incidence of resident history. Methods: Eighty patients with high altitude hypertension were randomly divided into nitrendipine and enalapril groups. Nitrendipine and enalapril 10 mg / d were given respectively. The changes of blood pressure were observed. Elisa and nitrate reduction Serum levels of ET-1 and NO were measured. Results: Enalapril and nitrets were able to lower their blood pressure and increase the content of vasodilator NO and the content of vasoconstrictor ET-1 in hypertensive patients with plateau residency, and the effect of nitrendipine Better than enalapril. CONCLUSION: Nitrendipine is superior to enalapril for hypertensive patients with a high incidence of resident history.