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目的研究香菇多糖对中晚期胃恶性肿瘤化疗增效减毒进行临床观察及安全性评价。方法回顾性分析山东省德州市宁津县人民医院2011年1月至2013年10月收治的52例胃癌患者,其中对照组25例,治疗组27例,对照组患者使用FOLFOX4方案,而治疗组患者在对照组基础上静脉滴注香菇多糖注射液。结果治疗组周围神经毒性、谷丙转氨酶升高水平、血小板下降水平、白细胞下降水平、胃肠道反应的发生率均明显低于对照组,差异有统计学意义(P<0.05);两组患者在尿素氮升高水平、肌酐升高水平方面差异无统计学意义(P>0.05)。对照组治疗后NK细胞、CD4+/CD8+、CD4+、CD3+均较治疗前有所下降,而治疗组治疗后NK细胞、CD4+/CD8+、CD4+、CD3+较治疗前明显升高,CD8+较治疗前降低,差异有统计学意义(P<0.05)。结论香菇多糖联合化疗能够提高中晚期胃恶性肿瘤患者的机体免疫功能、远期疾病控制率及化疗治疗效果,安全有效,还能够改善患者生活质量。
Objective To study the clinical observation and safety evaluation of lentinan on synergistic and attenuated chemotherapy of advanced gastric cancer. Methods Retrospective analysis of 52 cases of gastric cancer admitted to Ningjin County People’s Hospital of Dezhou, Shandong Province from January 2011 to October 2013, including 25 cases in the control group, 27 cases in the treatment group and FOLFOX4 in the control group, while the treatment group Patients in the control group based on intravenous infusion of lentinan injection. Results The peripheral neurotoxicity, elevated alanine aminotransferase, thrombocytopenia, leukopenia and the incidence of gastrointestinal reactions in the treatment group were significantly lower than those in the control group (P <0.05). There was no significant difference between the two groups There was no significant difference in the levels of urea nitrogen and creatinine (P> 0.05). The levels of NK cells, CD4 + / CD8 +, CD4 + and CD3 + in control group decreased after treatment compared with that before treatment, while the levels of NK cells, CD4 + / CD8 +, CD4 + and CD3 + in treatment group were significantly higher than those before treatment, The difference was statistically significant (P <0.05). Conclusion Lentinan combined with chemotherapy can improve the immune function of patients with advanced gastric cancer, long-term disease control and chemotherapy treatment effect, safe and effective, but also can improve the quality of life of patients.