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角化棘皮瘤(KA)是一种少见的皮肤鳞状上皮肿瘤,可自行消退。关于KA是独立的疾病,还是鳞状细胞癌(SCC)的低度变异,尚有争议。已知bcl-2蛋白作为癌基因蛋白表达于SCC。为探讨bcl-2蛋白在KA中的表达及其意义,我们对此进行了免疫组化检测。 7例KA均为石蜡包埋标本,包括4例增殖型和3例退化型,分型标准按文献。SP_(TM)
Keratoacanthoma (KA) is a rare skin squamous epithelial tumor that resolves on its own. It is controversial as to whether KA is an independent disease or a low degree of variability in squamous cell carcinoma (SCC). It is known that bcl-2 protein is expressed on SCC as an oncogene protein. To investigate the expression of bcl-2 protein in KA and its significance, we performed an immunohistochemical assay. 7 cases of KA were paraffin-embedded specimens, including 4 cases of proliferative type and 3 cases of degenerative type. SP_(TM)