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胃肠吻合后的上腹疼痛、胆汁性呕吐这一并发症的历史几乎与胃外科的历史一样古老.1881年即有人讨论了胃肠吻合后的症状与这种吻合的关系.1925年DaCosta认为胃肠吻合后恒定存在的胆汁入胃是无害的,且其硷性有对抗溃疡复发的作用.1951年,Wells等首次明确地描述了胃术后综合征与胆汁入胃的关系.本世纪60年代以来,对此“综合征”的认识明显加深.1964年,Lawson首先经动物实验将胆汁、胰液、胰胆汁混合液对胃枯膜的损害作用进行了比较.其后的报告陆续有:溃疡病并存的胃炎通常是萎缩性的,是由胆汁返流引起的;胆汁转流手术的应用;钡剂造影直接观察到的返流及同位素标记的鹅胆酸的返流;由胆汁所致的胃粘膜屏障损害及H~+的逆流等.1969年,VonHeerden提出用术后硷性返流性胃炎来命名这种胃术后并发症.70年代之后,对硷性返流性胃炎(Alkaline Reflux Gastritis,
The history of gastrointestinal complications such as abdominal pain and biliary vomiting is almost as old as the history of gastric surgery. The relationship between gastrointestinal anastomosis symptoms and this anastomosis was discussed in 1881. DaCosta The constant presence of bile into the stomach following gastrointestinal anastomosis is harmless and its alkalinity has the potential to counteract the recurrence of ulcers. In 1951, Wells et al. For the first time explicitly described the relationship between postoperative gastric complications and bile into the stomach. Since the 1960s, there has been a marked increase in the awareness of this “syndrome.” In 1964, Lawson first compared the harmful effects of bile, pancreatic juice, and pancreatic juice on gastric parietal cells through animal experiments. There are: gastritis coexisting with ulcer disease is usually atrophic, is caused by the bile reflux; application of biliary bypass surgery; barium directly observed reflux and isotope labeled gentioic acid reflux; from bile Caused by gastric mucosal barrier damage and H ~ + reflux, etc. In 1969, VonHeerden proposed postoperative alkaline reflux gastritis to name the postoperative complications of the stomach after the 70’s, the alkaline reflux gastritis (Alkaline Reflux Gastritis,