论文部分内容阅读
目的 :总结分析我院近年来静脉应用两性霉素B(AmB)治疗 5 5例隐球菌脑膜炎 (隐脑 )时发生的不良反应。方法 :回顾性分析 5 5例隐脑患者静脉应用AmB治疗过程中出现的各种不良反应 ,以及不良反应的防治措施。结果 :5 5例患者在静脉应用AmB治疗过程中有 5 3例发生各种不良反应 ,包括即刻反应、血细胞异常减少、肝肾功能损害、心脏毒性、低钾血症及静脉炎。其中 ,以肾、肝功能损害及低钾血症最为多见 ,其发生比率分别为 43.6 %、40 .0 %、38.2 %。本组资料还显示出现严重肝、肾功能损害及低钾血症的剂量较初次发生不良反应的剂量大 ,两者差异有显著性。结论 :AmB在长程治疗中会出现各种不良反应 ,应密切观察病情变化 ,定期随访 ,及时防治其不良反应的发生。
OBJECTIVE: To summarize and analyze the side effects of intravenous amphotericin B (AmB) in the treatment of 55 cryptococcal meningitis (crypto) in our hospital in recent years. Methods: A retrospective analysis of 5 5 cases of cryptorchid patients intravenous AmB treatment occurred during the various adverse reactions, and prevention and treatment of adverse reactions. RESULTS: Fifty-five patients experienced various adverse reactions in the course of intravenous AmB treatment, including immediate response, decreased blood cell abnormalities, impaired liver and renal function, cardiotoxicity, hypokalemia and phlebitis. Among them, kidney, liver damage and hypokalemia are the most common, the incidence rates were 43.6%, 40.0%, 38.2%. The data also showed that severe liver and kidney damage and hypokalemia than the initial dose of adverse reactions, the difference was significant. Conclusion: AmB will have various adverse reactions in long-term treatment. The changes of the disease should be closely observed and regularly followed up to prevent and control the occurrence of adverse reactions.