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Virtual supply chain based on cybermediary (VSC-CM)is an innovative VSC pattern meeting informationization development requirements in the manufacturing industry.Methods and features of customer-demand-oriented optimum VSC design adopted by CM are discussed.A customer demand goal system applying to VSC-CM design and quantifying methods of these goals are accordingly given.Then a three-stage optimum VSC design scheme based on dynamic goals is designed,which considers both the holistic optimization of VSC and individuation demands of member enterprises.To implement the scheme,an optimum algorithm synthesizing fuzzy c-means clustering algorithm and topsis comprchensive evaluation algorithm is presented.Feasibility and rapidity of this scheme is proved through a case analysis finally.