报道了新一代农药昆虫生长调节剂扑虱灵的急性、亚急性毒性和致突变性试验结果。扑虱灵SD大鼠经口急性LD_(50)雄性为6810mg/kg,雌性为5010mg/kg,经皮LD_(50)雌雄两性均>5000mg/kg。90天喂养亚慢性试验12500ppm组,动物体重增长率非常显著的降低,心、肝、肾、脾脏体比显著异常,肝肾功能和血红蛋白量有轻度改 ,2500ppm 组也出现毒性症状,据推算扑虱灵毒性阈剂量为250mg/kg,最大无作用剂量为50mg/kg。Ames和小鼠骨髓细胞微核试验结果均为阴性,提示扑虱灵无致突变性。 The results of the acute, subacute toxicity and mutagenicity tests of the new-generation pesticide insect growth regulator PentAmin were reported. The frequency of oral LD ​​50 males was 6810 mg/kg in male Sprague-Dawley rats and 5010 mg/kg in females and 5000 mg/kg in males and females. In the sub-chronic test 12500ppm group fed for 90 days, the animal body weight growth rate decreased significantly, the heart, liver, kidney, spleen body ratio was significantly abnormal, liver and kidney function and hemoglobin levels were slightly changed, and the 2500ppm group also exhibited toxic symptoms. Bufaxilin had a threshold dose of 250 mg/kg and a maximum no-action dose of 50 mg/kg. The micronucleus test results of Ames and mouse bone marrow cells were negative, suggesting that there is no mutagenicity.