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Angew.Chem.Int.Ed.2014,53,13740~13745受大自然多种酶催化的串联反应启发,结合不同催化剂的优势来发展新的不对称串联反应受到广泛关注.尽管利用两种催化剂实现的接力催化已经取得很大进展,但利用三种不同催化剂实现的不对称三重接力催化还有待发展.最近,华东师范大学化学与分子工程学院周剑课题组模块化组合钯催化的硝基还原、Br?nsted酸催化的酮亚胺形成和手性叔胺硫脲双功能催化的6π电环化反应这三步转化,实现了一个少见的一锅法三重串联接力催化的反应,能
Angew.Chem.Int.Ed.2014,53,13740 ~ 13745 Inspired by nature’s many enzyme-catalyzed tandem reactions, the development of new asymmetric tandem reactions with the advantages of different catalysts has drawn much attention. Despite the use of two catalysts Of the relay catalysis has made great progress, but the use of three different catalysts to achieve the asymmetric triplet relay catalysis yet to be developed.Recently, the East China Normal University Chemistry and Molecular Engineering Zhou Jian research group modular combination of palladium-catalyzed nitro reduction, Br? Nsted acid-catalyzed ketimine formation and chiral tertiary amine thiourea bifunctional catalysis of 6π electrocyclization reaction of these three-step conversion, to achieve an uncommon one-pot triple-series catalysis reaction can