目的对比分析高龄孕产妇与适龄孕产妇围生期血脂代谢与凝血功能指标的变化及其不良妊娠结局与妊娠并发症的发生情况。方法采用回顾性研究的方法,选取2015年1月-2016年10月在该院进行产前检查及分娩的高龄孕产妇158例(高龄孕产妇组),另选取同期非高龄孕产妇160例(对照组)。收集两组孕产妇妊娠28周以后至分娩期间产检时有关血脂指标、凝血功能指标、妊娠并发症、妊娠结局发生情况及分娩方式等资料。采用t检验及χ2检验进行统计学对比分析。结果高龄孕产妇组妊娠期高血压疾病及妊娠期糖尿病发生率与对照组有差别(P<0.05),而胎盘前置、产后出血、感染、胎膜早破及贫血发生率与对照组无差别(P>0.05);高龄孕产妇组围生儿胎儿生长缓慢、早产及胎儿窘迫发生率高于对照组(P<0.05);高龄孕产妇组剖宫产率高于对照组(P<0.05);高龄孕产妇组妊娠34周后TC及TG水平高于相应时期的对照组(P<0.05);低密度脂蛋白(LDL)和高密度脂蛋白(HDL)妊娠30周后高于相应时期的对照组(P<0.05);两组凝血功能指标在不同孕周均未见显著性差别(P>0.05)。结论妊娠期高血压疾病、妊娠期糖尿病是高龄孕产妇常见并发症,高龄妊娠易造成早产、胎儿窘迫及生长缓慢,高龄孕产妇剖宫产率升高。对于高龄孕产妇应加强围生期保健,检测凝血功能和血脂指标,有效监控其妊娠期并发症发生情况。 Objective To compare and analyze the changes of perinatal serum lipid metabolism and coagulation function and the incidence of adverse pregnancy outcomes and pregnancy complications in elder and pregnant women. Methods A retrospective study was conducted to select 158 ​​cases of elderly pregnant women who had prenatal examination and childbirth in the hospital from January 2015 to October 2016 and 160 pregnant women of the same age at the same period Control group). Two groups of pregnant women after 28 weeks of pregnancy to collect during childbirth seizure-related indicators of blood lipids, coagulation function, pregnancy complications, pregnancy outcome and delivery methods and other information. Using t test and χ2 test for statistical comparative analysis. Results The incidence of gestational hypertension and gestational diabetes in the elderly pregnant women group was significantly lower than that in the control group (P <0.05), while the incidence of placenta previa, postpartum hemorrhage, infection, premature rupture of membranes and anemia were not different from those in the control group (P> 0.05). The incidence of fetal growth in premature infants was slow, and the incidence of preterm birth and fetal distress was higher than that of the control group (P <0.05). The cesarean section rate of the elderly pregnant women was higher than that of the control group (P <0.05) (P <0.05). The level of TC and TG in geriatric maternal group after 34 weeks’ gestation was higher than those in corresponding period (P <0.05). LDL and HDL levels were higher in gestation group than those in corresponding period (P <0.05). There was no significant difference between the two groups in the gestational age (P> 0.05). Conclusion Hypertensive disorder in pregnancy and gestational diabetes mellitus are common complications of elderly pregnant women. Elderly pregnancy is likely to cause premature birth, fetal distress and slow growth. Cesarean section rate increases in older pregnant women. For older pregnant women should strengthen perinatal care, blood coagulation test and blood lipid indicators, effectively monitor the occurrence of complications during pregnancy.