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报告将头孢噻甲羧肟（ｃｅｆｔａｚｉｄｉｍｅ，ＣＡＺ）配成１％，５％，２０％三种浓度，分别在９０只豚鼠的中耳局部应用７ｄ后，再分别于停药７ｄ和１４ｄ，作组织形态学和听觉功能检查。结果：低浓度（１％，５％）组的豚鼠耳蜗铺片及扫描电镜观察均无明显变化，ＡＢＲ阈亦无提高。用高浓度（２０％）的豚鼠３耳（３／１０）扫描电镜见基底回外毛细胞部分融合变性、缺失，内毛细胞、指细胞及柱细胞形态学上无改变；停药后１４ｄ之豚鼠有７耳（７／１４）ＡＢＲ阈提高１５ｄＢ以上。提示低浓度的ＣＡＺ对内耳组织形态学和听觉功能无明显损害，有可能开发为高效、低毒的抗生素滴耳剂。
Reported ceftazidime (CAZ) dubbed 1%, 5%, 20% of the three concentrations, respectively, 90 guinea pigs in the middle ear after topical application of 7d, respectively, and then discontinued 7d and 14d, as tissue Morphological and auditory function tests. Results: There was no significant change in the cochlear implants and scanning electron microscopy in guinea pigs at low concentration (1%, 5%), but no increase in ABR threshold. With high concentration (20%) of guinea pigs 3 ears (3/10) scanning electron microscopy showed partial basal retrofacial hair cell fusion degeneration, deletion, inner hair cells, finger cells and columnar cells morphologically no change; 14d after drug withdrawal Guinea pigs have 7 ears (7/14) ABR threshold increased more than 15dB. Tip CAZ low concentrations of the inner ear morphology and auditory function without significant damage, it is possible to develop high-performance, low toxicity antibiotic ear drops.