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目的探讨抑癌基因p33ING1b在胆囊癌组织中的表达情况并探讨其临床意义。方法采用P免疫组化法测定p33ING1b蛋白在20例慢性胆囊炎及30例胆囊癌石蜡标本的阳性表达率及其与临床分级分期的相关性。结果 p33ING1b在胆囊癌中的表达率为53.33%(16/30)明显低于胆囊炎的100%(20/20),差异有显著意义(P<0.05)。胆囊癌中低分化组(25%)的表达明显低于高(76.92%)、中分化组(55.56%)。结论 p33ING1b在胆囊恶性肿瘤组织中呈低表达,其表达程度随着分化级别的降低而减少,表明胆囊恶性肿瘤中存在p33ING1b功能的缺失。
Objective To investigate the expression of tumor suppressor gene p33ING1b in gallbladder carcinoma and its clinical significance. Methods The positive rate of p33ING1b protein in 20 cases of chronic cholecystitis and 30 cases of gallbladder carcinomas was determined by P immunohistochemical method and its relationship with clinical stage and staging. Results The positive rate of p33ING1b in gallbladder carcinoma was 53.33% (16/30), which was significantly lower than that of cholecystitis (20/20). The difference was significant (P <0.05). The expression of gallbladder cancer in poorly differentiated group (25%) was significantly lower than in high (76.92%), moderately differentiated group (55.56%). Conclusion The expression of p33ING1b is low in gallbladder malignant tumors, and the expression of p33ING1b is decreased with the decreasing of differentiation grade. This indicates that p33ING1b is absent in gallbladder malignant tumors.