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目的探讨埃索美拉唑、阿莫西林与克拉霉素联合治疗幽门螺杆菌阳性(Hp)消化性溃疡并出血临床疗效。方法 2007年8月至2011年5月,收治Hp阳性并消化道出血的消化性溃疡患者168例,随机分为埃索美拉唑治疗组与对照组,治疗组用埃索美拉唑、阿莫西林与克拉霉素治疗,对照组用法莫替丁、阿莫西林与克拉霉素治疗,并对其疗效进行比较,用快速尿素酶检测Hp感染。治疗两周疗程结束后做胃镜复查。结果治疗组72h内出血得到控制77例,总有效(显效加有效)率97.47%;对照组出血得到控制59例,总有效率74.68%。两组对出血控制的总有效率差异有显著性(P<0.05)。两组比较溃疡愈合率和Hp根除率差异均有显著性(P<0.05)。结论埃索美拉唑、阿莫西林与克拉霉素联合治疗Hp阳性消化性溃疡并出血,疗效高患者依从性好,是治疗Hp阳性消化性溃疡并出血理想的药物组合。
Objective To investigate the clinical efficacy of esomeprazole, amoxicillin and clarithromycin in the treatment of peptic ulcer with Helicobacter pylori (Hp) hemorrhage. Methods From August 2007 to May 2011, 168 patients with peptic ulcer with positive Hp infection and gastrointestinal hemorrhage were randomly divided into esomeprazole treatment group and control group. The treatment group was treated with esomeprazole Moxillin and clarithromycin treatment, the control group with famotidine, amoxicillin and clarithromycin treatment, and its efficacy were compared with rapid urease detection of Hp infection. Treatment of two weeks after the end of the gastroscopy review. Results In the treatment group, hemorrhage was controlled in 77 cases within 72 hours. The total effective rate (effective rate) was 97.47%. In the control group, hemorrhage was controlled in 59 cases and the total effective rate was 74.68%. There was a significant difference between the two groups in the total effective rate of bleeding control (P <0.05). There was significant difference between the two groups in ulcer healing rate and Hp eradication rate (P <0.05). Conclusion Esomeprazole, amoxicillin and clarithromycin combined treatment of Hp-positive peptic ulcer bleeding, high efficacy in patients with good compliance, is the treatment of Hp-positive peptic ulcer bleeding and the ideal combination of drugs.