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目的探讨慢性阻塞性肺疾病(COPD)急性加重期和稳定期血清中胎盘生长因子(Pl GF)的水平,及其与高敏C反应蛋白(hs-CRP)和第一秒用力呼气容积(FEV1)的相关性。方法连续选择2011年12月至2012年10月就诊的COPD患者60例,其中急性加重期组和稳定期组各30例,同时纳入30例健康体检者为正常对照组。采用ELISA法和胶体金法,分别测定血清中Pl GF和hs-CRP的水平,并检测FEV1。所得资料采用非参数法和线性相关进行比较分析。结果 (1)3组Pl GF浓度的秩均值比较,急性加重期组高于稳定期组和正常对照组(P均<0.01),稳定期组亦高于正常对照组(P<0.01)。(2)3组hs-CRP浓度的秩均值比较,急性加重期组高于稳定期组和正常对照组(P均<0.01),稳定期组亦高于正常对照组(P<0.01)。(3)3组FEV1占预计值百分比的秩均值比较,急性加重期组均低于稳定期组和正常对照组(P均<0.01),稳定期组亦比正常对照组低(P<0.01)。(4)急性加重期组和稳定期组Pl GF与FEV1均呈负相关(r=-0.465,-0.402,P均<0.05)。结论 COPD患者尤其是急性期患者血清中Pl GF的水平增高,并与FEV1呈负相关,提示Pl GF参与COPD的发病过程。
Objective To investigate the serum level of placental growth factor (Pl GF) in acute exacerbation and stable phase of chronic obstructive pulmonary disease (COPD) and its relationship with high sensitivity C-reactive protein (hs-CRP) and forced expiratory volume in the first second (FEV1 ) Relevance. Methods Sixty consecutive COPD patients were selected from December 2011 to October 2012. Among them, 30 patients in acute exacerbation group and 30 patients in stable phase group were enrolled as normal control group. Serum levels of Pl GF and hs-CRP were measured by ELISA and colloidal gold respectively, and FEV1 was detected. The data obtained by non-parametric method and linear correlation for comparative analysis. Results (1) Compared with the stable group and the normal control group (P <0.01), Pl rank and average concentration of Pl GF in the three groups were also significantly higher than those in the normal control group (P <0.01). (2) Compared with the stable group and the normal control group (P <0.01), the average value of hs-CRP concentration in the three groups was also higher than that in the normal control group (P <0.01). (3) Compared with the normal group and the normal group, the average value of FEV1 in the three groups was lower than that in the stable group and the normal control group (P <0.01), and also lower in the stable group than in the normal control group (P <0.01) . (4) There was a negative correlation between Pl GF and FEV1 (r = -0.465, -0.402, P <0.05) in acute exacerbation group and stable fibrosis group. Conclusions The serum level of PlGF in patients with COPD, especially in acute phase, is increased and negatively correlated with FEV1, suggesting that Pl GF is involved in the pathogenesis of COPD.