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目的:探讨高频雾化吸入3%高渗盐水联合氨溴索治疗中、重度毛细支气管炎的疗效,为治疗毛细支气管炎提供参考。方法:采取随机对照方法,将85例中、重度毛细支气管炎住院患儿分成治疗组43例和对照组42例。在常规抗感染、止咳、化痰、雾化吸入激素、沙丁胺醇平喘治疗下,治疗组给予3%高渗盐水1.5 mL+盐酸氨溴索注射液15 mg高频雾化吸入,2次/d;对照组予生理盐水1.5 mL+盐酸氨溴索注射液15 mg高频雾化吸入,2次/d。两组疗程均为7～10 d。比较两组咳嗽、喘息、肺部湿啰音消失时间及住院时间、不良反应及住院费用。结果:两组患儿均痊愈出院,但治疗组在其咳嗽、喘息、肺部干湿啰音消失时间、住院时间及住院费用等方面均优与对照组(P<0.05)。结论:3%高渗盐水联合氨溴索高频雾化吸入是治疗中、重度毛细支气管炎的一种有效方法,并能减少住院时间,降低治疗费用。
Objective: To investigate the efficacy of high-frequency atomization inhalation of 3% hypertonic saline combined with ambroxol in the treatment of moderate and severe bronchiolitis, and provide a reference for the treatment of bronchiolitis. Methods: A randomized controlled trial was divided into treatment group (n = 43) and control group (n = 42). 85 children with moderate or severe bronchiolitis were enrolled. The patients in the treatment group were given 1.5% 3% hypertonic saline and ambroxol hydrochloride 15 mg high-frequency atomized inhalation twice a day for the treatment of conventional anti-infective, cough and phlegm, nebulized inhalation hormone and albuterol asthma. In the control group, saline 1.5 mL + ambroxol hydrochloride injection 15 mg high-frequency atomized inhalation 2 times / d. The two courses of treatment were 7 ~ 10 d. The cough, wheezing, disappearance of lung arachis, hospital stay, adverse reactions and hospitalization costs were compared between the two groups. Results: The two groups of children were cured and discharged. However, the treatment group was superior to the control group in cough, wheezing, disappearance of pulmonary wet and dry rales, hospital stay and hospital expenses (P <0.05). CONCLUSION: High-frequency inhalation of 3% hypertonic saline combined with ambroxol is an effective method for the treatment of moderate and severe bronchiolitis, and can reduce hospitalization time and reduce the cost of treatment.