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用放免法测定56例支气管肺癌患者、106例肺心病患者和229例健康人血清胃泌素含量，并比较39例肺癌患者放化疗前后血清胃泌素含量变化。结果显示：肺癌组血清胃泌素含量显著高于肺心病组和健康成人组（P＜0．05，P＜0．01），小细胞肺癌组高于鳞癌和腺癌组（P＜0．01），Ⅲ～Ⅳ期高于Ⅰ～Ⅱ期（P＜0．05）；在肺癌组中，放、化疗后血清胃泌素含量显著低于治疗前水平（P＜0．05）；血清中胃泌素测定对肺癌诊断的敏感性为68．7％，特异性为74．8％。表明血清胃泌素的测定有助于肺癌的诊断及分型、分期和预后的估计。
The radioimmunoassay was used to determine the serum gastrin content in 56 patients with bronchial lung cancer, 106 patients with pulmonary heart disease and 229 healthy people. The changes of serum gastrin content in 39 lung cancer patients before and after radiotherapy and chemotherapy were compared. The results showed that the serum gastrin content in lung cancer group was significantly higher than that in pulmonary heart disease group and healthy adult group (P<0.05, P<0.01). The small cell lung cancer group was higher than that in squamous cell carcinoma and adenocarcinoma group (P<0 .01), stage III ~ IV was higher than stage I ~ II (P <0.05); in the lung cancer group, serum gastrin content after radiotherapy and chemotherapy was significantly lower than before treatment (P <0.05); The sensitivity of serum gastrin determination in the diagnosis of lung cancer was 68.7%, and the specificity was 74.8%. It shows that the determination of serum gastrin is helpful for the diagnosis and classification of lung cancer, staging and prognosis estimation.