目前,国内外用于研究成人呼吸窘迫综合征(ARDS)的实验动物模型,主要是由静脉内注入油酸或内毒素及其他多种方法来复制。但这些模型有的在病因上,有的在病理变化方而,有的在模型复制的稳定性方面,更重要的是在血气变化等方面与临床存在着较大的差距。鉴于ARDS多发生在严重创伤后,特别是多发性长管状骨骨折病人,提示其发生与自身骨髓成分的释放有着某种关联。为此,本室自1982年在广泛收集有关资料的基础上,经反复试验,首次发现静脉内注入同种家兔长骨骨髓提取液(简称“髓液”),可复制出与临床相似、较为稳定、可靠的急、慢性RDS动物模型。现报道如下: At present, the experimental animal models used to study adult respiratory distress syndrome (ARDS) both at home and abroad mainly reproduce by intravenous injection of oleic acid or endotoxin and many other methods. However, some of these models are etiological, some in the pathological changes, and some in the model of the stability of replication, more importantly, there is a big gap in blood gas and clinical aspects. In view of ARDS often occur in patients with severe trauma, especially in patients with multiple long tubular fractures, suggesting that its occurrence has some connection with the release of bone marrow components. To this end, the room from 1982 in extensive collection of relevant information on the basis of repeated tests, for the first time found that intravenous injection of the same kind of long bone marrow extract of rabbits (referred to as “medullary fluid”), can be copied and clinical similar, more Stable, reliable acute and chronic RDS animal models. Reported as follows now: