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清道夫受体是一类结构多样的跨膜糖蛋白受体,已知的清道夫受体包括有7种类型:A、B、C、D、E、F、G。其中CD36作为B族清道夫受体之一,可以在多种细胞如巨噬细胞、微血管内皮细胞、血小板、脂肪细胞及上皮细胞(包括肾小管上皮细胞)等表达,参与多种生理病理过程[1-2]。本文就CD36及其在慢性肾间质损害中的最新研究进展作一综述。一、CD36的结构人类CD36的基因定位于第7号染色体的q11.2位点上,有15个外显子,长32kb。外显子1、2、15不编码。外显子3和14
Scavenger receptors are a diverse class of transmembrane glycoprotein receptors. Known scavenger receptors include seven types: A, B, C, D, E, F, Among them, CD36 is one of the group B scavenger receptors and can be expressed in many kinds of cells such as macrophages, microvascular endothelial cells, platelets, adipocytes and epithelial cells (including renal tubular epithelial cells), and is involved in various physiological and pathological processes [ 1-2]. This article reviews the recent progress of CD36 and its role in chronic interstitial damage. First, the structure of CD36 Human CD36 gene located on chromosome 7 q11.2 locus, there are 15 exons, 32kb long. Exons 1, 2, 15 do not encode. Exons 3 and 14