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目的:探讨氨基脲(semicarbazide,SEM)对雄性小鼠生殖功能的影响。方法:40只无特定病原体(specific pathogen free,SPF)清洁级健康成年KM雄性小鼠按体重随机分成为4组,每组分为10只:溶剂对照组、低剂量SEM染毒组、中剂量SEM染毒组、高剂量SEM染毒组。溶剂对照组用去离子水灌胃;SEM染毒组按30、60、120mg/kg.bw SEM溶液灌胃染毒6周,1次/日。最后灌胃24h后,将其剖杀,取其血液和组织器官检测相关生殖指标。结果亚慢性SEM可致雄性小鼠生殖系统损伤。
Objective: To investigate the effect of semicarbazide (SEM) on reproductive function in male mice. Methods: Forty healthy male KM mice with clean pathological grade SPF were randomly divided into 4 groups according to body weight: 10 in each group: solvent control group, low dose SEM group, medium dose SEM exposure group, high-dose SEM exposure group. The solvent control group was drenched with deionized water; SEM exposure group by 30,60,120mg / kg.bw SEM solution gavage for 6 weeks, 1 time / day. The last 24 hours after gavage, the beating, whichever blood and tissues and organs related reproductive indicators. Results Subchronic SEM can cause reproductive system injury in male mice.