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目的观察贝那普利和舒血宁注射液联合用药治疗高血压左室舒张功能不全的临床疗效。方法将36例原发性高血压左室舒张功能不全患者随机分为对照组和试验组,两组均给予基础治疗,试验组加用贝那普利和舒血宁注射液20ml,疗程2周。观察治疗前后两组舒张早期最大血流速度(E峰)、舒张晚期最大血流速度(A峰)、峰值速度比值(E/A)、左室射血分数(LVEF)的变化及总体疗效。结果治疗后两组临床症状均有好转。试验组的总有效率高于对照组,优效性检验成立。同时,治疗组舒张功能指标E/A比值、A峰、E峰改善优于对照组。结论贝那普利联合舒血宁注射液能明显改善高血压左室舒张功能不全者的临床症状和心功能指标。
Objective To observe the clinical effects of combination of benazepril and shuxuening injection on left ventricular diastolic dysfunction in patients with hypertension. Methods Thirty-six patients with essential hypertension with left ventricular diastolic dysfunction were randomly divided into control group and experimental group. Both groups were given basic treatment. The patients in trial group received benazepril and Shuxuening injection 20ml for 2 weeks. The changes of peak early diastolic velocity (E peak), peak diastolic velocity (A peak), peak velocity ratio (E / A), left ventricular ejection fraction (LVEF) and the overall curative effect were observed before and after treatment. Results After treatment, the clinical symptoms of both groups improved. The total effective rate of the experimental group was higher than that of the control group, and the superiority validity test was established. At the same time, the E / A ratio, A peak and E peak in the treatment group were better than those in the control group. Conclusion The combination of benazepril and shuxuening injection can obviously improve the clinical symptoms and cardiac function of patients with left ventricular diastolic dysfunction in hypertensive patients.