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肝移植患者术后虽然使用免疫抑制剂,但也可能发生急性排斥反应,出现肝功能下降、移植物损伤等不良预后,是早期移植失败的主要原因及影响移植后患者长期生存的危险因素。白细胞介素10(IL-10)是主要由Th2细胞产生的抑制性细胞因子,具有抑制体内Th1型细胞因子的产生、降低单核细胞表面主要组织相容性复合体Ⅱ的表达、阻断巨噬细胞作用等功能,下调一系列免疫反应。由于对免疫耐受的重要作用,在肝移植排斥反应的机制、预测、诊断以及治疗方面,IL-10得到了广泛深入的研究,是最有研究前景和价值的细胞因子之一。
Although immunosuppressive agents are used postoperatively in patients with liver transplantation, acute rejection may also occur, resulting in poor prognosis such as decreased liver function and graft injury, which are the main causes of early graft failure and the risk factors affecting the long-term survival of patients after transplantation. Interleukin-10 (IL-10), an inhibitory cytokine mainly produced by Th2 cells, inhibits the production of Th1-type cytokines in vivo and reduces the expression of major histocompatibility complex II on the surface of monocytes. The role of macrophages and other functions, down a series of immune response. Due to its important role in immune tolerance, IL-10 has been extensively studied in the mechanism, prediction, diagnosis and treatment of liver allograft rejection and is one of the most promising cytokines.