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目的探讨系统性炎症反应与慢性阻塞性肺疾病(COPD)继发肺动脉高压的关系.方法69例 COPD 患者行心脏彩色多普勒超声,根据安静状态下收缩期的肺动脉压(SPAP)分为肺动脉高压组(SPAP ≥30mmHg)和单纯 COPD 组(SPAP<30mmHg),分别测定两组患者的血浆 C 反应蛋白、内皮素-1(ET-1)及肿瘤坏死因子(TNF)-α.结果肺动脉高压组(n=36)患者血浆 C 反应蛋白为7.5mg/L[(5.0~10.8)mg/L],内皮素-1为52.6pg/mL[(48.6~54.5)pg/mL],肿瘤坏死因子-α为35.9 pg/mL[(24.1~54.3)pg/mL],均明显高于单纯 COPD 组(n=33):C 反应蛋白为4.0mg/L[(1.5~5.5)mg/L],内皮素为46.0pg/mL[(44.8~53.7)pg/mL],肿瘤坏死因子-α为27.8 pg/mL[(19.7~40.1)pg/mL].肺动脉高压组患者 C 反应蛋白、内皮素-1、肿瘤坏死因子-α与收缩期的肺动脉压呈正相关(r 分别为0.45、0.61、0.56,P 均<0.05).结论 C 反应蛋白、内皮素-1及肿瘤坏死因子-α与 COPD 患者肺动脉压力升高有关,提示炎症反应是慢性阻塞性肺疾病(COPD)继发肺动脉高压形成的重要因素.“,”Objective To investigate the relationship between systemic inflammatory response and pulmonary hypertention in chronic obstructive pulmonary disease(COPD). Methods Sixty-nine COPD patients were enroled in this study. Al subjects were divided into two groups according to color Doppler ultrasound of the heart, which defined as pulmonary hypertention and non pulmonary hypertention group.The plasma CRP,ET-1 and TNF-α were completed on each COPD patient. Results CRP, ET-1 and TNF-α showed significantly higher values in pulmonary hypertention group(7.5mg/L[(5.0 ~ 10.8)mg/L],52.6pg/mL[(48.6 ~ 54.5)pg/mL],35.9 pg/mL[(24.1 ~ 54.3)pg/mL],respectively) compared with non pulmonary hypertention group(4.0mg/L[(1.5 ~ 5.5)mg/L], 46.0pg/mL[(44.8 ~ 53.7)pg/mL], 27.8 pg/mL[(19.7 ~ 40.1)pg/mL],respectively).In pulmonary hypertention group SPAP was positively correlated with CRP,ET-1 and TNF-α respectively (r=0.45,0.61,0.56,P<0.05). Conclusion inflammatory response is one of the factors which related to pulmonary hypertention in COPD patients.