本文报道52个硝硫氰胺的衍化物,经对小鼠抗日本血吸虫筛选结果表明,其中8个化合物有抗日本血吸虫作用。化合物23对家兔血吸虫病的疗效较硝硫氰胺明显为高。对其中的6个化合物经棉鼠丝虫病实验治疗,发现化合物2和26有抗丝虫病作用,化合物26对微丝蚴和成虫的杀灭作用,不亚于海群生。药理研究正在进行中。 In this paper, 52 derivatives of nitrosamide were reported. The results of screening mice against Schistosoma japonicum showed that 8 of these compounds had anti-Schistosoma japonicum effect. The efficacy of compound 23 on rabbits with schistosomiasis was significantly higher than with nitrosamine. Six of these compounds were treated with experimental studies of Filariasis in Mice, Compounds 2 and 26 were found to have anti-filariasis activity and Compound 26 was shown to kill microfilariae and adults only as much as seaquamous. Pharmacological research is underway.