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钙的拮抗剂异搏定已广泛应用于临床,最近报道,它可以代替抗精神病药治疗躁狂症。一般常用的神经阻滞剂都有严重的副作用,而该药没有或仅有轻微的副作用。丁二苯哌啶类(dipenyibutylpiperidines,BPDP)如哌咪清和双苯烷胺(diphenylalkydamines,DPAA)如异搏定的分子结构受到注意。受体研究显示,DPBP是强效的钙通道拮抗剂,与异搏定类药物的作用部位相同,酚噻嗪类和丁酰苯类神经阻滞剂对钙没有强大的拮抗作用。DPBP对钙通道的阻断作用几乎与它阻断多巴胺受体的作用同样强大,提示治疗剂量的这类药物可能影响钙通道。
Verapamil, an antagonist of calcium, has been widely used clinically, recently reported that it can replace mania in the treatment of antipsychotics. Commonly used nerve blockers have serious side effects, but the drug has no or only minor side effects. Dipeptidyl piperidines (DPDPs) such as pethidine and diphenylalkydamines (DPAA) are noticed as the molecular structure of verapamil. Receptor studies have shown that DPBP is a potent calcium channel antagonist with the same site of action as verapamil, and that phenothiazines and butyrophenone blockers do not have a strong antagonistic effect on calcium. The blockade of calcium channels by DPBP is almost as strong as its blockade of dopamine receptors, suggesting that the therapeutic doses of these drugs may affect calcium channels.