论文部分内容阅读
肿瘤坏死因子α(TNFα)是多效性细胞因子,由活化的巨噬细胞和单核细胞等多种细胞产生。类风湿关节炎(RA)患者滑膜和滑液中已检测到TNFα,颞颌关节内紊乱(TMJID)和TMJ骨关节炎的滑液中也发现有TNFα。累及TMJ的慢性炎症性结缔组织病患者的主要临床表现是TMJ疼痛和异常性疼痛(allodynia)。本研究目的是确定慢性炎症性结缔组织病患者TMJ滑液(SF)及血浆(P)中TFNα水平,以及与TMJ疼痛、痛觉过敏和异常性疼痛的关系。 24例慢性炎症性结缔组织病伴TMJ疼痛的患者,女17例,男7例。RA 12例,其中7例血清类风湿因子阳性。非RA中牛皮癣性关节病4例,骨盆脊椎炎、慢性非特异性关节炎、Marfan综合征各2例,骨关节炎、Sj(?)gren综合征各l例。平均年龄45
Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine produced by a variety of cells such as activated macrophages and monocytes. TNFα was also found in synovial and synovial fluid of rheumatoid arthritis (RA) synovial fluid in which TNFα, TMJID (TMJID) and TMJ osteoarthritis were detected. The main clinical manifestations of TMJ patients with chronic inflammatory connective tissue disease are TMJ pain and allodynia. The purpose of this study was to determine the level of TFNa in TMJ synovial fluid (SF) and plasma (P) in patients with chronic inflammatory connective tissue disease and its relationship to TMJ pain, hyperalgesia and allodynia. 24 patients with chronic inflammatory connective tissue disease with TMJ pain, 17 females, 7 males. RA 12 cases, of which 7 cases of serum rheumatoid factor positive. Non-RA in 4 cases of psoriatic arthrosis, pelvic spondylitis, chronic non-specific arthritis, Marfan syndrome in 2 cases, osteoarthritis, Sj (?) Gren syndrome in l cases. The average age of 45