【摘 要】
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Three phthalide-derived analogues,oxaspiroangelioic acids A-C (1-3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads (guitou).Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HP
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia M
论文部分内容阅读
Three phthalide-derived analogues,oxaspiroangelioic acids A-C (1-3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads (guitou).Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HPLC.Their structures including absolute configurations were determined by spectroscopic data analysis,single crystal X-ray diffraction,exciton chirality method and electronic circular dichroism (ECD) calculation.These compounds share an undescribed carbon skeleton,for which biosynthetic pathways are proposed.Compound 1 and its enantiomers showed almost identical activity inhibiting Tandem of P domains in a weak inwardly rectifying K+ channel 1 (TREK-1).
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