为了深入了解慢性肾功能不全患者心血管系统并发症,探讨其发生机理,我们对20名正常人,20名肾功能正常的肾脏病人,20名肾功能代偿的肾脏病人,20名氮质血症期的肾脏病人,20名尿毒症期的肾脏病人进行了心率变异性测定。心率变异性以SDNN、SDANN_(index)、SDNN_(index)rMSSD、PNN_(50)、LF/HF作为观察指标。结果显示:肾功能不全患者随着肾功能损伤程度的加重,SDNN、SDANN_(index)、SDNN_(index)、rMSSD对逐渐降低。提示慢性肾功能不全患者有心脏植物神经功能的减退,心脏自主调节功能的下降,并且随着肾功能损伤程度的加重而加重。 In order to understand the cardiovascular complications in patients with chronic renal insufficiency and to explore its mechanism, we investigated 20 normal subjects, 20 renal patients with normal renal function, 20 renal patients with compensated renal function, 20 azotemia patients The renal disease patients, 20 uremic patients with renal disease were measured heart rate variability. The heart rate variability (SDNN), SDANN index, SDNN index (rMSSD), PNN_ (50), and LF / HF were observed. The results showed that SDNN, SDANN index, SDNN index and rMSSD decreased gradually with the severity of renal dysfunction in patients with renal insufficiency. Prompt patients with chronic renal insufficiency have decreased cardiac autonomic function, decreased cardiac autonomic function, and aggravated with the severity of renal dysfunction.