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目的:探讨复方丹参滴丸对动脉粥样硬化合并肝损害患者血脂的影响。方法:将107例高脂血症患者分为丹参滴丸组42例和他汀组65例,其中肝功能不全或对他汀类药物过敏者给予丹参滴丸治疗,其余给予他汀类药物治疗,对比2组间降脂的疗效以及复方丹参滴丸对肝功能的影响。结果:复方丹参滴丸在降低血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)方面疗效与阿托伐他汀钙相当,对高密度脂蛋白(HDL-C)改善不明显,但能改善已被损害的肝功能。结论:复方丹参滴丸是治疗高脂血症合并肝功能不全患者安全、有效的药物之一。
Objective: To investigate the effect of Compound Danshen Dripping Pills on blood lipids in patients with atherosclerosis complicated with liver damage. METHODS: One hundred and seventy patients with hyperlipidemia were divided into 42 patients in the Danshen Dripping Pill group and 65 in the statin group. Patients with hepatic insufficiency or those who were allergic to statins were treated with Danshen Dripping Pills. The rest were given statins for treatment. The effect of lipid-lowering therapy between groups and the effect of compound Danshen Dripping Pills on liver function. RESULTS: Compound Danshen Dripping Pills had the same efficacy as atorvastatin calcium in reducing serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) ) The improvement is not obvious, but it can improve the liver function that has been damaged. Conclusion: Compound Danshen Dripping Pill is one of the safe and effective drugs for the treatment of hyperlipidemia patients with hepatic insufficiency.