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目的了解原发性肝癌(PHC)临床特点,为PHC的防治提供依据。方法采用回顾性调查方法,对310例PHC住院患者的临床资料进行分析。结果80%以上的患者以非特异性症状与体征就诊,12.26%因并发症、合并症或转移症状就诊,3.55%因体检异常就诊;在有病理诊断的病例中,肝细胞癌占70.7%(29/41);HBV感染率为81.61%,男性高于女性(P<0.01);AFP阳性率为70.5%,HBV感染者AFP阳性率明显高于非HBV感染者(P<0.01);2.9%具有血吸虫病史,33.23%有嗜烟、酒史;4.52%具有PHC家族史。结论HBV感染是PHC的主要病原学因素,嗜酒、吸烟及血吸虫病等也可能是肝癌的风险因素。积极预防和控制HBV感染流行,是减少PHC发生的关键所在;定期对健康人群尤其是高危人群进行B超、AFP等检测,早发现、早治疗是提高原发性肝癌生存率的关键。
Objective To understand the clinical features of primary liver cancer (PHC) and provide the basis for the prevention and treatment of PHC. Methods The retrospective investigation method was used to analyze the clinical data of 310 PHC inpatients. Results More than 80% of the patients were treated with nonspecific symptoms and signs, 12.26% were diagnosed as complications, complications or metastasis, 3.55% were diagnosed as physical abnormalities, and 70.7% were diagnosed with pathological findings / 41). The infection rate of HBV was 81.61%, higher in males than in females (P <0.01). The positive rate of AFP was 70.5%. The positive rate of AFP in HBV infected patients was significantly higher than that in non-HBV infected patients (P <0.01) The history of schistosomiasis, 33.23% with smoking, alcohol history; 4.52% with PHC family history. Conclusion HBV infection is the main etiological factor of PHC. Alcohol abuse, smoking and schistosomiasis may also be the risk factors of HCC. Active prevention and control of the prevalence of HBV infection is the key to reducing the occurrence of PHC. Regular detection of B-type ultrasound and AFP in healthy people, especially those at high risk, early detection and early treatment are the keys to improve the survival rate of primary liver cancer.