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多发性骨髓瘤(MM)是以骨髓微环境中浆细胞恶性增殖为特征的血液肿瘤。细胞核因子κB受体活化因子配基(RANKL) /护骨素(OPG)与MM发病关系密切。在MM中,存在RANKL表达上调、OPG表达下调;这种RANKL/OPG比率异常与MM骨病及骨病范围、MM的肿瘤负荷、分期和预后均有关。
Multiple myeloma (MM) is a blood tumor characterized by malignant proliferation of plasma cells in the bone marrow microenvironment. RANKL / OPG is closely related to the pathogenesis of MM. In MM, RANKL expression was up-regulated and OPG expression was down-regulated. The abnormality of RANKL / OPG ratio was related to the range of MM bone disease and bone disease, the tumor burden, staging and prognosis of MM.