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目的:探讨外阴鳞癌(VSCC)中转化生长因子-β2(TGF-β2)和转化生长因子受体βRⅡ(TGFβRⅡ)蛋白的表达及其临床病理意义。方法:收集30例外阴鳞癌及10例外阴整形时切下的外阴正常皮肤组织。所有组织来自2012年1月至2015年10月在我院妇科行手术治疗的患者。采用免疫组化方法检测TGF-β2及TGFβRⅡ蛋白的表达。结果:外阴鳞癌组织中TGF-β2的阳性表达率显著高于正常外阴组织(90%vs 20%),差异有统计学意义(P<0.05),TGF-β2的表达与肿瘤分化程度、FIGO分期无关(P>0.05),但与淋巴结是否转移显著相关(P<0.05)。外阴鳞癌组织中TGFβRⅡ的阳性表达低于正常外阴组织(13.33%vs 70%),差异有统计学意义(P<0.05),TGFβRⅡ的表达与肿瘤分化程度、FIGO分期和淋巴结是否转移均无显著相关性(P>0.05)。结论:TGF-β2的表达上调与外阴鳞癌的发生及其淋巴结转移有关,可能是VSCC的治疗靶点。TGFβRⅡ的表达下调可能参与了外阴鳞癌的发生。
Objective: To investigate the expression of transforming growth factor-β2 (TGF-β2) and transforming growth factor receptor βRⅡ (TGFβRⅡ) in vulvar squamous cell carcinoma (VSCC) and its clinicopathological significance. Methods: 30 cases of vulvar squamous cell carcinoma and 10 cases of vulva vulva normal skin excision were collected. All organizations were from January 2012 to October 2015 in our hospital gynecological surgical patients. Immunohistochemistry was used to detect the expression of TGF-β2 and TGFβRⅡ. Results: The positive rate of TGF-β2 in vulvar squamous cell carcinoma was significantly higher than that in normal vulva (90% vs 20%, P <0.05). The expression of TGF-β2 was correlated with tumor differentiation, FIGO Stage (P> 0.05), but not with lymph node metastasis (P <0.05). The positive expression of TGFβRⅡ in vulvar squamous cell carcinoma was lower than that in normal vulvar tissue (13.33% vs 70%) (P <0.05). The expression of TGFβRⅡ was not correlated with tumor differentiation, FIGO stage and lymph node metastasis Correlation (P> 0.05). Conclusion: The upregulation of TGF-β2 is associated with the occurrence of vulvar squamous cell carcinoma and its lymph node metastasis, which may be the therapeutic target of VSCC. Down-regulation of TGFβRⅡ may be involved in the occurrence of vulvar squamous cell carcinoma.